pentobarbital will lessen the level or effect of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.pentobarbital will lessen the extent or result of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.fentanyl transdermal and pentobarbital both maximize sedation. Stay clear